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Colloidal Gold Nanoparticles for Biomedical Applications

Jyothy G. Vijayan

Abstract


The main problem of drug-based therapy is that the introduced compound is not located in the target area and it is widely dispersed. Colloidal nanoparticle-based treatment can benefit the situation. The human body can concentrate inert nanoparticle by passive targeting. The therapeutic delivery system can be promoted using the surface of gold nanoparticle so that it only targets the specific issues by active targeting. In passive targeting colloidal GNPs can be designed so that it can fit enough to be sustained in the liver and spleen while passing through other organs in the body. This therapy can be used for liver cancer. Because sinus endothelium of the organ has openings of 150 nm and spleen filters out particles greater than 250nm in size O’Neal et al reported that gold nanoshells (diameter 130 nm) would pass through the vessel. In auto-targeting, the more advanced approach is to functionalize the surface of the nanoparticle with an antibody or ligand for the desired target is used. By this specific activity, Biosynthesized GNPs is used - against Multi drug resistant pathogens, as antimicrobial/disinfection techniques in clinical instruments (medical textiles, catheters, etc.), as formulations with antibiotics for effective activity, in tagging with several compounds like polymers, proteins, etc. for effective antimicrobial activity and in many home appliances and water treatment.

Keywords: Drug, GNPs, colloidal, nanomedicine

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References


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