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Extracellular One Pot Green Synthesis of Palladium Nanoparticles

B. M. RATHORE, G M Nazeruddin, S R Prasad, D R KUMBHAR, R. V. Khandare, N R PRASAD

Abstract


Extracellular in-situ synthesis of metal nanoparticles using extracts of plants like Azadirachta indica (Neem), and Zingiber officinale (Ginger) has been successfully carried out earlier. In this study, we have developed a novel method to synthesize Palladium nanoparticles by the process of bio-chemical reaction between Palladium salt solution with seed extract of Coriandrum sativum without using any surfactant or external energy. By this method, physiologically stable, bio-compatible Pd nanoparticles (NPs) were formed. These functionalized PdNPs could be used for targeted drug delivery with enhanced therapeutic efficacy and minimal side effects. It is well known that on treating the metallic salt solution with some plant extracts, a rapid reduction occur leading to the formation of highly stable metal nanoparticles. This method resulted in rapid synthesis of nanoparticles i.e. reaction time was 1 to 2 hours as compared to 2 to 4 days required by microorganisms. These nanoparticles were analyzed by various characterization techniques to reveal their morphology, and chemical composition. SEM image of these NPs indicated the formation of spherical, non-uniform, poly dispersed nanoparticles. A detailed study of anti-microbial activity of nanoparticles and its synergetic effectiveness with common narrow spectrum antibiotic has been successfully carried out. Keywords: PdNPs, green synthesis, Coriandrum sativum, SEM, antimicrobial

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