Open Access Open Access  Restricted Access Subscription or Fee Access

Nanosuspension-novel Technique for Solubility Enhancement

A. Krishna Sailaja, Alekhya Amand

Abstract


In the treatment of many diseases, getting medicinal compounds to the desired location is a serious issue. Poor biodistribution, limited effectiveness, unfavorable side effects, and a lack of selectivity define traditional medication use. Different types of nanostructures are produced using various size reduction processes and technologies, each with its own set of physicochemical and biological features. These technologies make nanostructures a good material for biomedical applications, and they've gained a lot of traction in pharmacological research. Furthermore, these strategies aid in the reduction of toxicity, the enhancement of release, the improvement of solubility and bioavailability, and the provision of superior drug formulation chances. Nano suspension is a technique for preparing lowsoluble drugs for parenteral administration. The advantages of this technique are the small particle sizes (less than one micron) and the low solubility drug for parenteral administration.


Keywords


Nanoparticles, Nano-suspension, low solubility, dissolution, drug, Particle size.

Full Text:

PDF

References


Patel VR, Agrawal YK. Nanosuspension: An approach to enhance solubility of drugs. J Adv Pharm Technol Res. 2011;2(2):81-87. doi:10.4103/2231-4040.82950

Patel, V. R., & Agrawal, Y. K. (2011). Nanosuspension: An approach to enhance solubility of drugs. Journal of advanced pharmaceutical technology & research, 2(2), 81–87. https://doi.org/10.4103/2231-4040.82950

Patel, Vishal R, and Y K Agrawal. “Nanosuspension: An approach to enhance solubility of drugs.”Journal of advanced pharmaceutical technology & research vol. 2,2 (2011): 81-7.doi:10.4103/2231-4040.82950

Arunkumar N, Deecaraman M, Rini C. Nano-suspension-technology and its applications in drug delivery. Asian J Pharm 2009;3:168-73.

Lenhardt T, Vergnault G, Grenier P, Scherer D, Langguth P. Evaluation of nanosuspension for absorption enhancement of poorly soluble drugs: in-vitro transport studies across intestinal epithelial monolayers. AAPS J 2008;10:435-8.

Vaneerdenbrugh B, Vandenmooter G, Augustijns P. Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products. Int J Pharm 2008;364:64–75.

Muller RH, Jacobs C, Kayser O. Nanosuspensions as particulate drug formulations in drug therapy.Rationale for development and what we can expect for the future. Adv Drug Delivery Rev 2001;47:3-1

Smita S Aher, Sagar T Malsane, RB Saudagar. Nanosuspension: an overview. Int J Curr Pharm Res 2017;9(3):19-23.

Jacob, S., Nair, A.B. & Shah, J. Emerging role of nanosuspensions in drug delivery systems. Biomater Res 2020,24, 3. https://doi.org/10.1186/s40824-020-0184-8

V B Patravale, Abhijit A Date, R M Kulkarni, Nanosuspensions: a promising drug delivery strategy, Journal of Pharmacy and Pharmacology, Volume 56, Issue 7, July 2004, Pages 827–840,

Kawabata Y, Wada K, Nakatani M, Yamada S, Onoue S. Formulation design for poorly watersoluble drugs based on biopharmaceutics classification system: basic approaches and practical applications. Int J Pharm. 2011;420:1–10.

Singh A, Worku ZA, Van den Mooter G. Oral formulation strategies to improve solubility of poorly water-soluble drugs. Expert Opin Drug Deliv. 2011;8:1361–78.


Refbacks

  • There are currently no refbacks.