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Educational Research – Review on the Integrated Microfluidic Devices for Multifarious Bioengineering Applications
Abstract
The integrated microfluidic devices may contain many fluidic, electronic, mechanical and chemical connections on a single micron-scale chip towards the operations of microfluidic laboratory-on-a-chip systems, fluidic micro-electromechanical systems (MEMS), and micro total analysis systems (µTAS). This type of microfluidic devices are useful in many biological and chemical applications like DNA analysis, separation-based detection, cell handling, cell sorting, protein-based applications, immunoassays, chemical analysis, chemical detection, and chemical processing. These applications may acquire sufficient impact in the biomedical industry in near future. This review work is useful as study material for the proposed elective-course on Microfluidics (M.Tech, Theory) in the Department of Mechanical Engineering of the National Institute of Technology Arunachal Pradesh, India.
Keywords: cell sorting, DNA analysis, immunoassay, microfluidic device
REFERENCES
[1] D. Erickson, D. Li. Integrated microfluidic devices, Anal Chim Acta. 2004; 507: 11–26p.
[2] S. Mukhopadhyay, J. P. Banerjee, A. Mathur, M. Tweedie, J. A. McLaughlin, S. S. Roy. Experimental studies of surface-driven capillary flow in PMMA microfluidic devices prepared by direct bonding technique and passive separation of microparticles in microfluidic laboratory-on-a-chip systems, Surf Rev Lett. 2015; 22: 1550050p.
[3] S. Mukhopadhyay, J.P. Banerjee, S.S. Roy, S.K. Metya, M. Tweedie, J.A. McLaughlin. Effects of surface properties on fluid engineering generated by the surface-driven capillary flow of water in microfluidic lab-on-a-chip systems for bioengineering applications, Surf Rev Lett. 2017; 24: 1750041p.
[4] S. Mukhopadhyay. Optimisation of the experimental methods for the fabrication of polymer microstructures and polymer microfluidic devices for bioengineering applications, J Polym Compos. 2016; 4: 8–26p.
[5] S. Mukhopadhyay. Experimental Investigations on the interactions between liquids and structures to passively control the surface-driven capillary flow in microfluidic lab-on-a-chip systems to separate the microparticles for bioengineering applications, Surf Rev Lett. 2017; 24: 1750075p.
[6] S. Mukhopadhyay. Experimental Investigations on the surface-driven capillary flow of aqueous microparticle suspensions in the microfluidic laboratory-on-a-chip systems, Surf Rev Lett. 2017; 24: 1750107p.
[7] S. Mukhopadhyay. Experimental investigations on the effects of surface modifications to control the surface-driven capillary flow of aqueous working liquids in the PMMA microfluidic devices, Adv Sci Eng Med. 2017; 9: 959–70p.
[8] S. Mukhopadhyay. Report on the separation efficiency with separation time in the microfluidic lab-on-a-chip systems fabricated by polymers in this 21st century of 3rd millennium, J Exp Appl Mech. 2016; 7: 20–37p.
[9] C.W. Tsao, D.L. DeVoe. Bonding of thermoplastic polymer microfluidics, Microfluid Nanofluid. 2009; 6: 1–16p.
[10] H. Becker, L.E. Locascio. Polymer microfluidic devices, Talanta. 2002; 56: 267–87p.
Keywords: cell sorting, DNA analysis, immunoassay, microfluidic device
REFERENCES
[1] D. Erickson, D. Li. Integrated microfluidic devices, Anal Chim Acta. 2004; 507: 11–26p.
[2] S. Mukhopadhyay, J. P. Banerjee, A. Mathur, M. Tweedie, J. A. McLaughlin, S. S. Roy. Experimental studies of surface-driven capillary flow in PMMA microfluidic devices prepared by direct bonding technique and passive separation of microparticles in microfluidic laboratory-on-a-chip systems, Surf Rev Lett. 2015; 22: 1550050p.
[3] S. Mukhopadhyay, J.P. Banerjee, S.S. Roy, S.K. Metya, M. Tweedie, J.A. McLaughlin. Effects of surface properties on fluid engineering generated by the surface-driven capillary flow of water in microfluidic lab-on-a-chip systems for bioengineering applications, Surf Rev Lett. 2017; 24: 1750041p.
[4] S. Mukhopadhyay. Optimisation of the experimental methods for the fabrication of polymer microstructures and polymer microfluidic devices for bioengineering applications, J Polym Compos. 2016; 4: 8–26p.
[5] S. Mukhopadhyay. Experimental Investigations on the interactions between liquids and structures to passively control the surface-driven capillary flow in microfluidic lab-on-a-chip systems to separate the microparticles for bioengineering applications, Surf Rev Lett. 2017; 24: 1750075p.
[6] S. Mukhopadhyay. Experimental Investigations on the surface-driven capillary flow of aqueous microparticle suspensions in the microfluidic laboratory-on-a-chip systems, Surf Rev Lett. 2017; 24: 1750107p.
[7] S. Mukhopadhyay. Experimental investigations on the effects of surface modifications to control the surface-driven capillary flow of aqueous working liquids in the PMMA microfluidic devices, Adv Sci Eng Med. 2017; 9: 959–70p.
[8] S. Mukhopadhyay. Report on the separation efficiency with separation time in the microfluidic lab-on-a-chip systems fabricated by polymers in this 21st century of 3rd millennium, J Exp Appl Mech. 2016; 7: 20–37p.
[9] C.W. Tsao, D.L. DeVoe. Bonding of thermoplastic polymer microfluidics, Microfluid Nanofluid. 2009; 6: 1–16p.
[10] H. Becker, L.E. Locascio. Polymer microfluidic devices, Talanta. 2002; 56: 267–87p.
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