Biosynthesis, characterization of gold nanoparticles using M. indica leaf extractand their anticancer activity

Abstract

The present study involves the novel approach for the synthesis of nanomaterial holds infinite possibilities as nanotechnology has a major impact on medicine and its application. Leaf extract of Mangiferaindicais a very good bioreductant for gold chloride (HAuCl4·4H2O) which leads to the synthesis of gold nanoparticles. Leaf extract of Mangiferaindicawas mixed with gold chloride (HAuCl4·4H2O) and UV-vis spectroscopy was used to detect the synthesis of nanoparticles. TEM and FESEM were used for size, shape and structural morphology of synthesized nanoparticles. Synthesized gold nanoparticles were in range of less than ~75nm and hexagonal in shape. The gold nanoparticles also showed potent cytotoxic effect against A549 lung cancer cell lines with an IC 50 value of 59 μg/ml/24 h by the MTT assay Keywords: Biosynthesis, Characterization, Cytotoxicity Gold chloride, Nanotechnology