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Design and Evaluation of Ethionamide as Dry Powder Inhaler for Pulmonary Administration
Abstract
Ethionamide nanosuspension was prepared using Tween-80+ Span-80 as surfactant. Ethionamide nanoparticles were prepared using method known as media milling Method. Method to reduce dose and control frequency. It is further developed as a dry powder inhaler, making it suitable for lung control and the residence time of the drug in the lungs is prolonged. Ethionamide nanoparticles were prepared by ambient grinding method. The freeze-dried and anhydrous lactose-free nanoparticles were mixed using a geometric dilution technique to convert the nanoparticles into a dry powder inhaler form. Ethionamide nanoparticles showed % drug release 98.39 ± 3.59% in 1 h. The aerodynamic particle size of the optimized dry powder inhaler was found to be 1.39 µm. During the 1-month safety study, dry powder inhalers found no significant aggregation.
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DOI: https://doi.org/10.37628/ijn.v9i1.1001
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