Preparation of Diclofenac Sodium Loaded Invasomes - A Novel Carrier for Drug Delivery

Abstract

Background: Diclofenac sodium is capable of providing benefit to patients suffering from: rheumatoid arthritis, osteoarthritis, and gout. Diclofenac sodium is a medicine that reduces inflammation and pain. It is also used to treat aches and pains, as well as problems with joints, muscles, and bones. The aim of the present work is to prepare diclofenac sodium invasomes by thin film hydration technique. Methodology: In the present study, for the preparation of diclofenac sodium loaded invasomes by thin film hydration technique. The obtained formulations were studied for characterization and evaluation parameters. Results: Among all three formulations F1 formulation prepared by using 1:1 ratio of drug and lipid at 400 rpm was showing promising results with drug content as 52.51% and drug release of 72.48% were able to sustain the drug release for 12 hours. Conclusions: In this study diclofenac sodium invasomes were prepared by thin film hydration method by using soya lecithin as lipid and using span 60 as surfactant. This study was performed to determine parameters such as drug content and drug release. F1 formulation was considered as the best formulation as it shown best and promising results.