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Experimental Demonstration on the Recording of Capillary-Filled Microfluidic Devices Fabricated by Polymeric Material

Subhadeep Mukhopadhyay

Abstract


In this present experimental work, total 52 individual PMMA microfluidic devices are fabricated by maskless lithography, hot embossing lithography and direct bonding technique in a cleanroom laboratory. The selected working liquids are dyed water, dyed aqueous ethanol and dyed aqueous isopropyl alcohol and are prepared in a materials-science laboratory. Fabricated microfluidic devices are tested by the prepared aqueous working liquids, and each capillary-filled device after the surface-driven microfluidic flow is recorded by a CMOS camera in the same materials-science laboratory. In this work, leakage-free sealing is achieved in each fabricated microfluidic device according to the recorded snap-shot images. This present experimental work will be useful in commercial applications like bioengineering laboratory-on-a-chip systems.

Keywords: Polymer, Plasticity, Microfluidic Device, Capillary-filled, Microchannel bend, Sudden expansion microchannel


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References


H. Becker, L. E. Locascio, “Polymer Microfluidic Devices”, Talanta, Vol. 56 (2002) Pages 267-287.

S. Song, K. Y. Lee, “Polymers for Microfluidic Chips”, Macromolecular Research, Vol. 14, No. 2 (2006) Pages 121-128.

U. M. Attia, S. Marson, J. R. Alcock, “Micro-Injection Moulding of Polymer Microfluidic Devices”, Microfluid Nanofluid, Vol. 7 (2009) Pages 1-28.

Y. Sun, Y. C. Kwok, “Polymeric Microfluidic System for DNA Analysis”, Analytica Chimica Acta, Vol. 556 (2006) Pages 80-96.

R. E. Robertson, “Theory for the Plasticity of Glassy Polymers”, The Journal of Chemical Physics, Vol. 44, No. 10 (1966) Pages 3950-3956.

N. M. Ames, “A Thermo-Mechanical Finite Deformation Theory of Plasticity for Amorphous Polymers: Application to Micro-Hot-Embossing of poly(methyl methacrylate)”, Thesis, 2007, Massachusetts Institute of Technology, USA.

H. Becker, U. Heim, “Hot Embossing as a Method for the Fabrication of Polymer High Aspect Ratio Structures”, Sensors and Actuators, Vol. 83 (2000) Pages 130-135.

P. Datta, J. Goettert, “Method for Polymer Hot Embossing Process Development”, Microsyst Technol, Vol. 13 (2007) Pages 265-270.

P. Kern, J. Veh, J. Michler, “New Developments in Through-Mask Electrochemical Micromachining of Titanium”, Journal of Micromechanics and Microengineering, Vol. 17 (2007) Pages 1168-1177.

A. A. Saha, S. K. Mitra, “Effect of Dynamic Contact Angle in a Volume of Fluid (VOF) Model for a Microfluidic Capillary Flow”, Journal of Colloid and Interface Science, Vol. 339 (2009) Pages 461-480.

J. W. Suk, J. H. Cho, “Capillary Flow Control using Hydrophobic Patterns”, Journal of Micromechanics and Microengineering, Vol. 17 (2007) Pages N11-N15.

A. A. Saha, S. K. Mitra, M. Tweedie, S. Roy, J. McLaughlin, “Experimental and Numerical Investigation of Capillary Flow in SU8 and PDMS Microchannels with Integrated Pillars”, Microfluid Nanofluid, Vol. 7 (2009) Pages 451-465.

J. Lee, B. He, N. A. Patankar, “A Roughness-Based Wettability Switching Membrane Device for Hydrophobic Surfaces”, Journal of Micromechanics and Microengineering, Vol. 15 (2005) Pages 591-600.

G. Croce, P. D’Agaro, “Numerical Simulation of Roughness Effect on Microchannel Heat Transfer and Pressure Drop in Laminar Flow”, Journal of Physics D: Applied Physics, Vol. 38 (2005) Pages 1518-1530.

G. Gamrat, M. Favre-Marinet, S. L. Person, R. Baviere, F. Ayela, “An Experimental Study and Modelling of Roughness Effects on Laminar Flow in Microchannels”, Journal of Fluid Mechanics, Vol. 594 (2008) Pages 399-423.

X. Q. Wang, C. Yap, A. S. Mujumdar, “Effects of Two-Dimensional Roughness in Flow in Microchannels”, Journal of Electronic Packaging, Vol. 127 (2005) Pages 357-361.

M. Sbragaglia, R. Benzi, L. Biferale, S. Succi, F. Toschi, “Surface Roughness-Hydrophobicity Coupling in Microchannel and Nanochannel Flows”, Physical Review Letters, Vol. 97 (2006) Page 204503.

A. S. Rawool, S. K. Mitra, S. G. Kandlikar, “Numerical Simulation of Flow through Microchannels with Designed Roughness”, Microfluid Nanofluid, Vol. 2 (2006) Pages 215-221.

Y. F. Chen, F. G. Tseng, S. Y. ChangChien, M. H. Chen, R. J. Yu, C. C. Chieng, “Surface Tension Driven Flow for Open Microchannels with Different Turning Angles”, Microfluid Nanofluid, Vol. 5 (2008) Pages 193-203.

S. Mukhopadhyay, J. P. Banerjee, A. Mathur, M. Tweedie, J. A. McLaughlin, S. S. Roy, “Experimental Studies of Surface-Driven Capillary Flow in PMMA Microfluidic Devices Prepared by Direct Bonding Technique and Passive Separation of Microparticles in Microfluidic Laboratory-on-a-Chip Systems”, Surface Review and Letters, Vol. 22 (2015) Page 1550050.

S. Mukhopadhyay, J. P. Banerjee, S. S. Roy, S. K. Metya, M. Tweedie, J. A. McLaughlin, “Effects of Surface Properties on Fluid Engineering Generated by the Surface-Driven Capillary Flow of Water in Microfluidic Lab-on-a-Chip Systems for Bioengineering Applications”, Surface Review and Letters, Vol. 24 (2017) Page 1750041.

S. Mukhopadhyay, “Experimental Investigations on the Durability of PMMA Microfluidic Devices Fabricated by Hot Embossing Lithography with Plasma Processing for Bioengineering Applications”, Emerging Trends in Chemical Engineering, Vol. 3, Issue 3 (2016) Pages 1-18.

S. Mukhopadhyay, “Experimental Investigations on the Effects of Channel Aspect Ratio and Surface Wettability to Control the Surface-Driven Capillary Flow of Water in Straight PMMA Microchannels”, Trends in Opto Electro and Optical Communications, Vol. 6, Issue 3 (2016) Pages 1-12.

S. Mukhopadhyay, “Experimental Investigations on the Interactions between Liquids and Structures to Passively Control the Surface-Driven Capillary Flow in Microfluidic Lab-on-a-Chip Systems to Separate the Microparticles for Bioengineering Applications”, Surface Review and Letters, Vol. 24 (2017) Page 1750075.

S. Mukhopadhyay, “Experimental Investigations on the Surface-Driven Capillary Flow of Aqueous Microparticle Suspensions in the Microfluidic Laboratory-on-a-Chip Systems”, Surface Review and Letters, Vol. 24 (2017) Page 1750107.

S. Mukhopadhyay, “Experimental Investigations on the Effects of Surface Modifications to Control the Surface-Driven Capillary Flow of Aqueous Working Liquids in the PMMA Microfluidic Devices”, Advanced Science, Engineering and Medicine, Vol. 9 (2017) Pages 959-970.




DOI: https://doi.org/10.37628/ijpse.v5i2.615

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